Table of Contents Chapter 1 Introduction 6 Chapter 2 Review: Is cardiac toxicity a relevant issue in the radiation treatment of esophageal cancer? 16 Published in Radiotherapy and Oncology 2015, Volume 114(85-90) Chapter 3 Editorial: Cardiac toxicity in the radiation treatment of esophageal cancer: an emerging concern. 32 Published in Future Cardiology 2015 Volume 11(4), 367-369 Chapter 4 Can we safely reduce the radiation dose to the heart while compromising the dose to the lungs in esophageal cancer patients? 38 Published in Radiotherapy and Oncology 2020, Volume 149(222-227) Chapter 5 Radiation induced myocardial fibrosis in long-term esophageal cancer survivors. 58 Published in Int J Radiation Oncol Biol Phys 2021, Volume 110(4), 1013-1021 Chapter 6 Late cardiac toxicity of neo-adjuvant chemoradiation in esophageal cancer survivors: a cross-sectional pilot study. 78 Published in Radiotherapy and Oncology 2022, Volume 167(72-77) Chapter 7 Blood biomarkers for cardiac damage during and after radiotherapy for esophageal cancer: a prospective cohort study 96 Published in Radiotherapy and Oncology 2024, Volume 200 Chapter 8 Summarized discussion and future perspectives. 114 Appendices Nederlandse samenvatting 134 Access to supplementary data 140 Curriculum Vitae 141 List of publications 142 Dankwoord 146
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