67 Myocardial fibrosis in esophageal cancer patients Surgery (n = 16) nCRT + Surgery (n = 17) Gender Male Female 13 3 11 6 P = 0.286 Age (years) 71.8 ± 9.6 67.6 ± 8.1 P = 0.180 Time after treatment (months) 122 ± 35 87 ± 23 P = 0.002 WHO PS 0 vs higher 10 (13) 11 (14) P = 0.895(0.935) BMI 25.5 ± 2.8 24.8 ± 5.1 P = 0.625 Smoking status Current smoker Past smoker 3 7 1 15 P = 0.024 Hypertension 3 (3) 6 (3) P = 0.289 (0.935) Diabetes Mellitus 1 (1) 7 (5) P = 0.019 (0.116) Hypercholesterolemia 2 6 P = 0.127 Coronary artery disease 2 (2) 1 (0) P = 0.509 (0.133) Atrial fibrillation 0 (0) 5 (1) P = 0.019 (0.325) Table 1: Patient characteristics and cardiac risk factors. Baseline (prior to treatment) values are shown between brackets. Radiation therapy and Chemotherapy All patients of the nCRT group received the full course of radiation and chemotherapy. On average, the mean heart dose (MHD) was 22.9 ± 4.0 Gy, with a mean dose to the cardiac substructures of 17.8 ± 5.8 Gy to the LV, 25.9 ± 4.9 Gy to the RV, 32.0 ± 8.1 Gy to the LA and 23.3 ± 8.3 Gy to the RA. The mean MLD was 7.5 ± 2.5 Gy and the mean V5 Gy of the lungs was 39.8 ± 15.8%. The left ventricular dose distribution is visualized in figure 3 and 4 using the mean dose per myocardial segment. 5
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