71 Myocardial fibrosis in esophageal cancer patients segment dose (Gy)), which seems to confirm our initial hypothesis that thoracic radiation induces dose-dependent (sub)clinical myocardial fibrosis. Differences in LV function were not found between patients with normal and elevated mean global ECV (supplementary data in Table E3) Figure 5. Scatter plot visualizing the effect of mean dose per left ventricular myocardial segment (x-axis) on extracellular volume (y-axis) in neoadjuvant chemoradiotherapy patients. Each dot represents one left ventricular myocardial segment of a patient. The association between radiation dose and increased extracellular volume that was established using mixed-model analysis with a random intercept is represented by the formula. 5
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