PADIT-score and device infection in pacemaker or defibrillator surgery 95 the C-statistic was between 0.50 and 0.70, good between 0.70 and 0.80, and excellent if > 0.80. Binary logistic regression analysis was performed to test the diagnostic properties of the optimal PADIT score threshold. Odds ratios will be presented with their corresponding 95% confidence intervals (CI). All analyses were two-tailed; a P-value < 0.05 was considered statistically significant. Statistical analyses were performed using SPSS software (SPSS, version 28.0.1.0; IBM, Chicago, IL). 3. Results 3.1 Study population A total of 2511 CIED procedures were performed during the study period. After the exclusion of patients who did not fulfil the eligibility criteria, the final study population consisted of 2333 CIED procedures in 2105 patients (Fig. 1). Baseline characteristics of the study population are presented in Table 1. The mean age at the time of the procedure was 61.6 ± 16.3 years and 64.5% were male. A previous CIED infection was present in 1.7%, and chronic kidney disease stage IV to V (eGFR < 30 ml/min) was present in 5.4%. One hundred twenty-seven patients (5.4%) were immunocompromised. The most common procedure was an ICD procedure (new or generator replacement, 42.6%), followed by a pacemaker procedure (new or generator replacement, 29.3%), CRT procedure (new or generator replacement, 16.6%), and revision and/or upgrade procedure (11.5%). A total of 1117 patients (47.9%) would be considered potential WRAP-IT patients (i.e., CIED reoperations and initial CRT-D implantation). The median PADIT score was 4 (IQR, 2–6). Figure 2 shows the distribution of the PADIT score in the study population. The proportion of patients with low (≤ 4 points), intermediate (5–6 points), and high-risk PADIT score (≥ 7 points) was 1403 (60.1%), 523 (22.4%), and 407 (17.4%), respectively. 3.2 Primary endpoint and PADIT-score Within 1 year of follow-up, hospitalization for CIED infection occurred in 10 patients (0.43%, 95% CI 0.21–0.79%). Details regarding the CIED infections are summarized in Table 2. Most cases occurred within the first 5 weeks after the procedure (80%) 6
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