167 S/F94 as a proxy for COVID-19 severity 7 Selection criteria SpO2≤ 0.94 or FIO2=0.21 SpO2>0.94 Day 0 and (SpO2≤ 0.94 or FIO2=0.21) Day 0 and SpO2>0.94 Number of entries 192,583 55,765 114,668 27,367 Unique subjects 129,049 39,457 114,688 27,367 Age, years 71 (57-82) 69 (55-82) 72 (58-83) 70 (55-82) Male 111,244 (58%) 32,022 (58%) 63,127 (55%) 15,351 (56%) Respiratory rate, per minute 20 (18-25) 22 (18-26) 20 (18-25) 22 (18-25) Temperature, Celcius 37.2 (36.838.0) 37.1 (36.737.8) 37.3 (36.838.1) 37.3 (36.838.1) Systolic blood pressure, mmHg 116 (103138) 120 (105140) 117 (104-138) 121 (106142) Diastolic blood pressure, mmHg 66 (57-77) 69 (59-77) 68 (58-79) 70 (60-81) CRP, mg/L 85 (39-159) 84 (39-152) 78 (34-145) 84 (40-149) BUN, mmol/L 7.0 (4.8-10.9) 6.7 (4.6-10.5) 6.7 (4.6-10.3) 6.5 (4.5-10.1) Creatinine, umol/L 86 (68-120) 84 (67-119) 88 (70-119) 86 (70-116) Urine production, ml/24h 1,001 (4001839) 1,020 (4501890) 500 (300-950) 550 (3001,000) Glasgow Coma Scale 15 (15-15) 15 (15-15) 15 (15-15) 15 (15-15) Clinical frailty 4 (2-6) 4 (2-6) 4 (3-6) 4 (2-6) Onset to admission, days 4 (0-8) 4 (0-8) 3 (0-7) 4 (0-8) Infiltrates on X-ray present 52,001 (67%) 14,525 (69%) 41,944 (63%) 12,147 (67%) No respiratory support (WHO 4) 71,633 (37%) 0 (0%) 11,187 (23%) 0 (0%) Nasal oxygen (WHO 5) 53,610 (28%) 23,220 (42%) 19,904 (41%) 10,102 (64%) Non invasive ventilation (WHO 6) 46,473 (24%) 11,764 (21%) 15,370 (32%) 5,148 (32%) IMV: SF >2.0 (WHO 7) 3,063 (2%) 1,789 (3%) 249 (<1%) 172 (1%) IMV: SF ≤ 2.0 or vasopressor (WHO 8) 8,782 (5%) 1.900 (3%) 1,174 (2%) 345 (2%) IMV: SF ≤ 2.0 and vasopressor, ECMO or dialysis (WHO 9) 3,004 (2%) 784 (1%) 401 (<1%) 151 (1%) Death (WHO 10) 30,225 (23%) 8,289 (21%) 26,017 (23%) 5,924 (22%) Discharged alive (including transfer to another facility) 98,824 (77%) 31,168 (79%) 88,651 (77%) 21,443 (78%) Supplementary Table 1. Characteristics of patient populations meeting criteria for S/F94 measurement in ISARIC4C data. Continuous values are summarised as median (inter quartile range). Categorical values are summarised as frequency (percentage). Subjects meeting the criteria for S/F94 (SpO2≤ 0.94 or FiO2 = 0.21) were compared to patients not meeting the S/F94 criteria. Comparison was done both for all entries during admission and day 0. CRP = C-reactive protein, BUN= blood urea nitrogen.
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