136 Table 5.2. Intra-observer and Interobserver Variability Test: UP Velocity and Coordination Features Were Extracted From TVUS Recordings Acquired From Ten Healthy Volunteers. ICC (95% Confidence Interval) of the Extracted Features Is Calculated Among Three Trails (Intra-observer) and Three Operators (Inter-observer) Feature Name ICC Intra-observer variability (95% CI) Inter-observer variability (95% CI) Velocity C2F 0.969 (0.910 – 0.992) 0.953 (0.866-0.987) Velocity F2C 0.921 (0.762-0.979) 0.965 (0.899-0.990) Coordination by CC 0.853 (0.589-0.960_ 0.752 (0.318-0.931) Coordination by MSE 0.841 (0.553-0.956) 0.762 (0.353-0.934) Coordination by Hd 0.863 (0.616-0.963) 0.785 (0.409-0.940) B. Validation in IVF Patients In total, 81 TVUS recordings (65 from the IMPLANT 1 study and 16 from Ghent University Hospital) were acquired from IVF patients 1 h before ET; 20 TVUS recordings from the IMPLANT 1 study had to be excluded because of improper imaging windows. The remaining 61 TVUS recordings underwent the proposed quantitative quality check, by which additional 11 TVUS recordings from the IMPLANT 1 study were excluded. All 16 TVUS recordings acquired at Ghent University Hospital passed the quality check. In the end, in total, 50 TVUS recordings were included for further analysis. Sixteen out of the selected 50 patients got pregnant after the treatment, while the remaining 34 failed. The UP MV in the C2F direction 1 h before ET was 0.51 (0.45 to 0.65) mm/s in the success group and 0.63 (0.57 to 0.74) mm/s in the failure group. When considering the C2F direction, the MV values were equal to 0.56 (0.52–0.65) mm/s in the successful group and 0.70 (0.61–0.74) mm/s in the unsuccessful group [see Figure5. 7A]. Significantly higher velocities in the C2F (p=0.0082 ) and F2C (p=0.0073 ) directions were found in the failure group compared to the success group.
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