201 Adenomyosis Patients For the adenomyosis group, women were included if they had sonographic markers for adenomyosis, based on (Morphological Uterine Sonographic Assessment (Morphological Uterine Sonographic Assessment, MUSA (183)) criteria. Women were also included if they had signs of adenomyosis on MRI (if available), according to MRI criteria as described in literature (29,181,199). The added presence of endometriosis was not considered as an exclusion criteria. Data sources and measurements: TVUS measurement: Transvaginal ultrasounds (TVUS) were performed during several phases of the menstrual cycle: the menstrual phase (M, cycle day (CD) 1-5), mid-follicular (MF, CD 6-10), late follicular phase (LF, CD 11-14), early luteal phase (EL, CD 15-20) and late luteal phase (LL, CD 21-28). Four-minute video recordings of the uterus in the mid-sagittal section were made. The ultrasound machines were: an Accuvix WA80S with Elite (Samsung Medison, Seoul, Korea) equipped with a V5-9 transvaginal probe (bandwidth 5-9 MHz) or a GE Voluson (GE Healthcare, Zipf, Austria) equipped with a RIC5-9W-RS probe (bandwidth 3.8-9.3MHz). Differences in speckle characteristics were corrected between both ultrasound platforms. Feature Extraction: Various uterine contractility features were extracted from the ultrasound recordings using a dedicated speckle tracking algorithm previously developed and implemented in Matlab software (Mathworks, Natick, USA). The full details of the methodology of feature extraction have been described in detail in previously published works (221,224,226–229). All contraction features were assessed separately for the anterior uterine wall (AW) and the posterior uterine wall (PW).
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