204 The UC features were compared between the adenomyosis and control group, according to the phase of the menstrual cycle. The UC features were then analysed in women with adenomyosis during the menstrual phase according to reported visual analogue scale (VAS) score. Demographic and clinical characteristics were also gathered for participating women, such as age, BMI, parity, cycle duration, medical history, uterine morphology on TVUS and history of subfertility. Statistical methods: Statistical analysis was performed using IBM SPSS statistics version 28. Counts and frequencies were compared between groups for patient and demographic characteristics. Categorical variables were reported as frequencies and compared using the chi squared test. Continuous variables were reported as means (and standard deviation) if normally distributed, and medians (with interquartile range) if abnormally distributed. Comparison of the outcome measures (frequency, amplitude, direction, coordination and velocity) between patient groups per cycle phase was done using the MannWhitney U test if abnormally distributed, and independent T-test if normally distributed. The association between the UC features and dysmenorrhea (VAS score) in the adenomyosis group during M phase was measured using the Pearson correlation coefficient. Statistical significance was defined as a pvalue < 0.05. This study is reported according to STROBE guidelines (189), see appendix 8A for the accompanying STROBE checklist. Ethical approval: This study received ethical approval from the local and regional ethical committees of participating centres, with study number NL52466.100.15. All participants gave informed consent prior to study participation. The WAVES study is registered in the Netherlands Trial Registry under number NL5035.
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