227 be guaranteed. Therefore, study group patients were matched to control group patients in a 1:2 ratio to reduce this influence on the outcome. A preference was given for exact matches. Outcomes The primary study outcomes were: biochemical pregnancy (positive serum HCG 16 days after embryo transfer (ET), ongoing pregnancy (a viable pregnancy 11 weeks after ET, with presence of foetal heartbeat on ultrasound) and live birth (delivery of a live foetus >24 weeks gestational age). Further patient characteristics collected included: age, BMI, indication for IVF/ICSI treatment, adenomyosis and/or endometriosis phenotypes, and IVF/ICSI treatment characteristics (type of subfertility (primary or secondary), infertility time (in months), treatment type (IVF or ICSI), fertilisation rate, embryo quality, number of transferred embryos). Full details and definitions of all outcomes can be found in Table A1 in Appendix A. Data sources Data regarding the IVF and ICSI cycles was taken from the Landelijk Specialistisch Fertiliteits Dossier (LSFD, Stichting Automatisering Fertiliteit (SAF), Utrecht, the Netherlands), the Dutch national electronic patient fertility database, and MRI data was taken from the local hospital patient records HiX (ChipSoft, Amsterdam, The Netherlands). Statistical analysis Data analysis was done using IBM SPSS Statistics Version 26. For normally distributed continuous variables, one-way ANOVA was used to evaluate differences between groups, the Kruskal-Wallis test was used in the case of abnormal distribution. A post-hoc test with Bonferroni correction was used to evaluate which groups showed significant differences. For categorical variables, differences between groups were evaluated using the Chi-square test using Bonferroni correction. Univariate and multivariate logistic regression (correcting for embryo quality) was carried out to calculate the odds ratio for primary outcomes for the study group(s) versus (matched) controls. A p-value <0.05 was considered statistically significant.
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