258 IVF/ICSI Outcomes: A complete overview of IVF/ICSI outcomes for the adenomyosis versus controls is seen in Table 10.S6. Overall, patients with MRI-diagnosed adenomyosis showed significantly fewer biochemical and ongoing pregnancies and live births versus controls in crude analysis (25% vs. 36.3%, p=0.013, 15.6% vs. 29.4%, p=0.001, and 14.0% vs. 26.8%, p=0.009, respectively). A sub-analysis of patients with only fair-to-super quality embryos was also carried out (see supplementary file, Table S5), with comparable results (p=0.010 ,p=0.002 and p=0.014, respectively in crude analysis). Subsequently, IVF/ICSI outcomes for patients with markers for adenomyosis or endometriosis severity were compared to controls (See Table 10.S6 for full results). Table 10.4 presents a sub-analysis of adenomyosis MRI markers and reports the live birth rate (LBR) and adjusted odds ratio’s for LB versus male infertility controls corrected for age at IVF, embryo quality, number of transferred embryos, and year of treatment. Results for BP and OP are shown in Table S7. Adenomyosis patients overall showed statistically significantly fewer LB compared to controls (aOR 0.560 (95% CI 0.318-0.988, p=0.045). The subanalysis for patients with only fair-to-super quality embryos showed comparable results (aOR 0.457 (95% CI 0.239-0.877, p=0.018) Furthermore, the MRI markers of myometrial cysts, JZ-Diff >5mm, JZ/Myometrium ratio >40% and added presence of endometriosis remained statistically significantly associated with fewer LB versus controls.
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