271 MATERIALS AND METHODS: Study Objective: To investigate the prevalence of adverse obstetric and neonatal outcomes in women with histopathological adenomyosis compared to that of that of the general (Dutch) population Study Design: Retrospective observational population-based cohort study Setting: Dutch population-level data from 1995-2018. Population: Inclusion criteria Study Group: Women between the ages of 18-50 histologically diagnosed with adenomyosis, from the Dutch nationwide pathology databank (PALGA) between the years of 1995 to 2018, with pregnancy outcomes registered in the Dutch national perinatal registry (Perined). Control group: Women between the ages of 18-50 with registered pregnancy outcomes in the Perined registry between the years 1995 to 2018, without reported histopathological adenomyosis diagnosis. Exclusion criteria No pseudonymised personal identifier in the perinatal registry, meaning that data linkage could not be facilitated. Sample Size calculation: Due to the still disputed prevalence of adenomyosis (288) and risk of adverse pregnancy outcomes in women with adenomyosis, a sample size calculation was not conducted. However, due to this study using population-level data is assumed that the power of the results is sufficient to yield clinically significant results.
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