iv 2B. Data extraction tables The following data was extracted from the included relevant studies. Table 2.S1 Data Extraction Table Studies Investigating Diagnostic Accuracy of MRI vs Histopathology Authors, year Study design e.g. retrospective/prospective cohort, pilot, feasibility, interventional, observational Study objective e.g. diagnostic accuracy, treatment evaluation, differentiating adenomyosis vs fibroids Study population (N) Study inclusion criteria e.g. symptomatic women receiving surgery, Study exclusion criteria e.g. using hormonal therapy, post-menopausal Comparison groups e.g. with adenomyosis vs. without adenomyosis (if applicable) (MRI vs. TVUS etc.) Adenomyosis definition used on MRI e.g. JZ >12mm on MRI, histopathological diagnosis, TVUS MUSA criteria, clinical symptoms MRI slice thickness (mm) e.g. 3mm, 4mm MRI systems used and manufacturer e.g. 1.5T, 3T MRI sequences/techniques/settings used e.g. T1/T2/DWI/DTI/T1-contrast-enhanced All MRI features investigated Signal intensity, JZ irregularity, JZ thickness etc. Objectified MRI features e.g. JZ thickness, JZ diff, JZ-Myometrium ratio etc., uterine size, lesion size, apparent diffusion coefficient Evaluation by experienced radiologist? Y/N MRI (re-)evaluated during the study or previous evaluation used? e.g. MRI evaluated during study, MRI conclusion used retrospectively (not validated) Multiple (blinded) radiologist evaluation? Y/N Menstrual cycle accounted for? e.g. MRI only conducted in proliferative phase Histopathological Reference diagnosis made Y/N Pathological definition of Adenomyosis e.g. 1/3 myometrial invasion, 2 fields invasion etc. Type of tissue sampled Hysterectomy or biopsy? Experienced (multiple) pathologists evaluating tissue? Diagnostic accuracy investigated Which element most accurate? Outcomes measured e.g. Symptom severity, menstrual blood volume, pain, change in uterine volume Results of Adenomyosis characteristics on MRI e.g. mean JZ thickness, mean uterine volume, # diffuse cases, # focal cases, Adenomyosis-related Results E.g. correlation with symptom reduction y/n, reduction in JZ thickness, degree of uterine volume reduction, diagnostic accuracy/specificity/sensitivity Number of adenomyosis diagnosis on MRI N= Number of adenomyosis diagnosed on histopathology N= Comments If any QUADAS-II Quality Assessment a. Patient selection
RkJQdWJsaXNoZXIy MTk4NDMw