xvii Dueholm et al. 2001 Presence of adenomyosis on histopathology No adenomyosis: Mean JZ Max: 10mm 14 22 Sensitivity 70%, Specificity 86% PPV 58%, NPV 91%. Higher JZ associated with more accurate MRI diagnosis (Cut-off: Max 12mm, Diff: 5-7mm) Hamimi et al. 2015 Confirmed diagnosis of adenomyosis after imaging NR Myometrial Cysts: 20 TP, 5 FP, 15 TN, 20 FN Heterogeneous myometrium: 38 TP, 5 FP, 15 TN, 2 FN, JZ >12mm: 42 TP, 1 FP, 15 TN, 2 FN 45 TP, but seemingly only 5 based on histopathology Myometrial cysts: Accuracy 58% Sensitivity 80%, Specificity 50% PPV 80%, NPV 43% Heterogeneous myometrium: Accuracy 88% Sensitivity 95%, Specificity 75% PPV 88%, NPV 88% JZ>12mm: Accuracy 95% Sensitivity 95%, Specificity 94% PPV 98%, NPV 88% Hricak et al. 1992 Correct diagnosis of adenomyosis in different MRI sequences vs. histopathology NR specifically 17 19 NR in study, 2 x 2 tables constructed by reviewer based on information provided in the paper. See from page 43 of the supplementary file for details. Masui et al. 2003** Diagnosis of adenomyosis (or leiomyoma) per different MRI method No difference in detection for different MRI techniques NR, calculated by reviewer See from page 43 of the supplementary file for details. 18 Accuracy: 82% Sensitivity: 69% Specificity: 67% PPV: 59% NPV: 90% Moghadam et al. 2006 Accurate diagnosis of leiomyoma/adenomyosis vs. histopathology NR 12 TP, 11 FP, 19 FN, 111 TN 31 Sensitivity 38%, Specificity 91% PPV 52% NPV 85% Phillips et al. 1996*** Diagnosis of adenomyoma on MRI vs. myometrial biopsy Mean adenomyoma volume: 125 +/- 12 cm^3 Mean uterine volume: 18TP, 2FP 18 Sensitivity: 100% Other diagnostic performance values NR.
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