xx Table 2.S6 Study Characteristics of Studies investigating Objective Measures of Adenomyosis on MRI Autho rs, Year Study Design Study objective Study population (N) Study Setting Study inclusion criteria Study exclusion criteria MRI Adenomyo sis definition used MRI Manufa cturer, Settings and Parame ters MRI features investigated Quantifiab le MRI Characteri stics investigate d Clinical Outcomes correlated with MRI Parameters ? Ander sson et al, 2016 (123) Multicentre, Prospect ive Pilot Study Evaluate vaginal bromocriptin e as treatment for symptoms of adenomyosi s 23 women with diffuse adenomyosi s Universit y hospital (Sweden ), and Tertiary Hospital (USA) Women aged 35-50 with regular heavy menstrual bleeding, with adenomyosis diagnosed by TVUS and MRI Women actively pursuing pregnancy, <6 months postpartum, breastfeeding) , Enlarged uterus over umbilical level, Contraindications to bromocriptine, MRI suggestive for endometriosis or prolactinoma, IUD, antidepressants, opioid medication, suspected (gynaecological) malignancy JZ > 12mm, JZ diff >5mm and ratio JZ/ myometriu m >40%, presence of myometrial cystic changes Manufa cturer: NR System: NR Slice Thicknes s: NR Sequen ces: NR Uterus size, JZ thickness, Cystic changes in JZ (unclear if on T1 or T2), Adenomyosis type, Presence of Fibroids, Fibroid size Uterus size (length, Anterior Myometriu m width, Posterior myometriu m width) JZ Max, JZ Min, JZ Diff, JZ/Myome trium Ratio No Bae et al. 2015 (130) Singlecentre, Retrospe ctive Intervent ional Cohort study To evaluate the effect of degree of necrosis after UAE on symptom recurrence at midterm 50 Women with symptomatic pure adenomyosi s (no fibroids) Universit y Hospital (Korea) Women with pure adenomyosis who had UAE treatment, and received MRI 3 months prior to and post- NR JZ >12mm with or without punctate HSI foci Manufa cturer: NR System: NR JZ thickness, Presence of HSI foci (on T1/T2), Necrosis percentage on CE MRI after JZ thickness, Uterine volume, Larger uterine volume associated with more symptom recurrence after
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