lxi Table 2.S9 Reference Standard: Risk of Bias and Applicability Author, Year Interpretation of histopathology Evaluated by experienced pathologist? Blinded to MRI diagnosis ? Likely to have correctly identify adenomyosi s using this method? Potential for bias in histopath ological diagnosis ? Does the application of the histopathologi cal diagnosis match the research question? Ascher et al. 1994 Endometrial glands and stroma lying deeper than 2.5 mm below the endometrial surface. Evaluated by pathologists, degree of experience unknown Unclear Yes High, not blinded Yes Badawy et al. 2014 NR NR Unclear Unclear Unclear, not mentione d if blinded Yes Bazot et al. 2001 Macroscopic: enlarged uterus and a dense anarchically fasciculated unlimited myometrium with small cavities (510mm(. Microscopic: presence of ectopic endometrial tissue within myometrium 2.5mm beyond the endometrial/ myometrial junction. Yes Yes, One pathologis t, blinded Yes Low Yes Bazot et al. 2003 Macroscopic: enlarged uterus and a dense anarchically fasciculated unlimited myometrium with small cavities (510mm(. Microscopic: presence of ectopic endometrial tissue within myometrium 2.5mm beyond the endometrial/ myometrial junction. Yes Yes Yes Low Yes
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