cvi Participants 13a Describe the flow of participants through the study, including the number of participants with and without the outcome and, if applicable, a summary of the follow-up time. A diagram may be helpful. 8 13b Describe the characteristics of the participants (basic demographics, clinical features, available predictors), including the number of participants with missing data for predictors and outcome. 8, 9 Model development 14a Specify the number of participants and outcome events in each analysis. 8, 9 14b If done, report the unadjusted association between each candidate predictor and outcome. 9-11 Model specification 15a Present the full prediction model to allow predictions for individuals (i.e., all regression coefficients, and model intercept or baseline survival at a given time point). 11 15b Explain how to the use the prediction model. 12 Model performance 16 Report performance measures (with CIs) for the prediction model. 9-11 Discussion Limitations 18 Discuss any limitations of the study (such as nonrepresentative sample, few events per predictor, missing data). 12-13 Interpretation 19b Give an overall interpretation of the results, considering objectives, limitations, and results from similar studies, and other relevant evidence. 12-13 Implications 20 Discuss the potential clinical use of the model and implications for future research. 13 Other information Supplementary information 21 Provide information about the availability of supplementary resources, such as study protocol, Web calculator, and data sets. - Funding 22 Give the source of funding and the role of the funders for the present study. 1
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