cxv 7B. Extensive risk of bias assessment Max. obtainable score Bulletti et al. (1997) Bulletti et al. (2002) Fornazari et al. (2019) Kido et al. (2007) Kido et al. (2011) Kido et al. (2014) Kissler et al. (2007) Leyendecker et al. (1996) Nishino et al. (2005) Oliva et al. (1992) Orisaka et al. (2007) Pinto et al. (2015) Qu et al. (2019) Szamatowicz et al. (1997) Yoshino et al. (2010) Yoshino et al. (2012) Reporting 1 Hypothesis / aim/ objective clearly described 1 1 1 1 1 1 1 0 1 1 0 1 1 1 1 1 1 2 Main outcomes in introductio n or methods section 1 1 1 1 1 1 1 0 1 1 0 1 1 1 1 1 1 3 Patient characteris tics clearly described 1 1 1 1 1 1 1 0 1 1 0 1 1 1 0 1 1 4 Interventio ns of interest clearly described 1 N/ A 0 1 N/ A 1 N/ A N/ A N/ A N/ A 1 N/ A N/ A 1 1 N/ A 1 5 Distributio ns of principal confounde rs clearly described 2 0 1 2 1 1 1 0 1 1 0 1 1 2 0 2 2 6 Main findings clearly described 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 7 Estimates of random variability provided for main outcomes 1 1 1 0 1 0 0 0 1 0 0 0 0 1 1 1 1 8 All adverse 1 N/ A 0 0 N/ A 0 N/ A N/ A N/ A N/ A 0 N/ A N/ A 0 0 N/ A 0
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