14800-DvRappard

101 Donor macrophages and remyelination in metachromatic leukodystrophy 6 14. Marteyn A, Sarrazin N, Yan J, Bachelin C, Deboux C, Santin MD, et al. Modulation of the Innate Immune Response by Human Neural Precursors Prevails over Oligodendrocyte Progenitor Remyelination to Rescue a Severe Model of Pelizaeus-Merzbacher Disease. Stem Cells. 2016;34:984-996. 15. Hawkins-Salsbury JA, Shea L, Jiang X, Hunter DA, Guzman AM, Reddy AS, et al. Mechanism- based combination treatment dramatically increases therapeutic efficacy in murine globoid cell leukodystrophy. J Neurosci . 2015;35:6495-6505. 16. Sessa M, Lorioli L, Fumagalli F, Acquati S, Redaelli D, Baldoli C, et al. Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial. Lancet. 2016;388:476-487. 17. Kevelam SH, Bugiani M, Salomons GS, Feigenbaum A, Blaser S, Prasad C, et al. Exome sequencing reveals mutated SLC19A3 in patients with an early-infantile, lethal encephalopathy. Brain . 2013;136:1534-1543. 18. Melief J, KoningN, Schuurman KG, VanDe GardeMD, Smolders J, Hoek RM, et al. Phenotyping primary human microglia: tight regulation of LPS responsiveness. Glia. 2012;60:1506-1517. 19. Ambarus CA, Krausz S, van Eijk M, Hamann J, Radstake TR, Reedquist KA, et al. Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods. 2012;375:196-206. 20. Durafourt BA, Moore CS, Zammit DA, Johnson TA, Zaguia F, Guiot MC, et al. Comparison of polarization properties of human adult microglia and blood-derived macrophages. Glia . 2012;60:717-727. 21. Depienne C, Bugiani M, Dupuits C, Galanaud D, Touitou V, Postma N, et al. Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study. Lancet Neurol . 2013;12:659-668. 22. Schneider CA, RasbandWS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9:671-675. 23. Ruifrok AC, Johnston DA. Quantification of histochemical staining by color deconvolution . Anal Quant Cytol Histol . 2001;23:291-299.