14800-DvRappard

133 Diffusion tensor imaging in metachromatic leukodystrophy 8 Figure 3 . Longitudinal evolvement of (A) FA in NAWM, (B) FA and (C) AD in corpus callosum, (D) FA in pyramidal tracts, (E) FA and (F) AD in thalamus. Control values are indicated in black, HCT- eligible patients in green and non-eligible patients in pink. Data measured at 1.5T are indicated with a circle, data measured at 3T with a triangle. After transplantation, symbols are filled. DISCUSSION Using diffusion-weighted MRI, we compared magnitude and direction of diffusion between MLD patients and controls to gain insight into the microstructure of affected brain tissue. At baseline, FA was decreased and MD and RD were increased in MLD patients compared to controls throughout the WM, not only in the corpus callosum (affected early in the disease), but also in NAWM. FA measures of the thalamus did not differ between groups, but its components AD and RD were both increased in patients