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137 Diffusion tensor imaging in metachromatic leukodystrophy 8 REFERENCES 1. Eckhardt M. The role and metabolism of sulfatide in the nervous system. Mol Neurobiol . 2008;37:93-103. 2. van Rappard DF, Boelens JJ, Wolf NI. Metachromatic leukodystrophy: Disease spectrum and approaches for treatment. Best Pract Res Clin Endocrinol Metab . 2015;29:261-273. 3. Groeschel S, Kuhl JS, BleyAE, Kehrer C, et al. Long-termOutcome of AllogeneicHematopoietic Stem Cell Transplantation in Patients With Juvenile Metachromatic Leukodystrophy ComparedWith Nontransplanted Control Patients. JAMA Neurol. 2016;73:1133-1140. 4. van Rappard DF, Boelens JJ, van Egmond ME, Kuball J, et al. Efficacy of hematopoietic cell transplantation in metachromatic leukodystrophy: the Dutch experience. Blood. 2016;127:3098-3101. 5. van der Knaap MS, Valk J. Magnetic Resonance of Myelination and Myelin Disorders. Third ed. Springer Berlin Heidelberg New York; 2015. 6. Tillema JM, Derks MG, Pouwels PJ,Pimde Graaf, et al. Volumetric MRI data correlate to disease severity in metachromatic leukodystrophy. Ann Clin Transl Neurol . 2015;2:932-940. 7. Martin A, Sevin C, Lazarus C, Bellesme C, et al. Toward a better understanding of brain lesions during metachromatic leukodystrophy evolution . Am J Neuroradiol. 2012;33:1731-1739. 8. van der Voorn JP, Pouwels PJ, Kamphorst W, Powers JM, et al. Histopathologic correlates of radial stripes on MR images in lysosomal storage disorders. Am J Neuroradiol . 2005;26:442- 446. 9. Assaf Y, Pasternak O. Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci. 2008;34:51-61. 10. Basser PJ, Jones DK. Diffusion-tensor MRI: theory, experimental design and data analysis - a technical review. NMR Biomed. 2002;15:456-467. 11. Jones DK, Knosche TR, Turner R. White matter integrity, fiber count, and other fallacies: the do's and don'ts of diffusion MRI. Neuroimage . 2013;73:239-254. 12. Song SK, Sun SW, Ramsbottom MJ, Chang C, et al. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage . 2002;17:1429-1436. 13. Song SK, Yoshino J, Le TQ, Lin SJ, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage . 2005;26:132-140. 14. Klawiter EC, Xu J, Naismith RT, Benzinger TL, et al. Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosis. Mult Scler . 2012;18:1259- 1268. 15. Alexander AL, Lee JE, Lazar M, Field AS. Diffusion tensor imaging of the brain. Neurotherapeutics . 2007;4:316-329. 16. Boretius S, Escher A, Dallenga T, Wrzos C, et al. Assessment of lesion pathology in a new animal model of MS by multiparametric MRI and DTI. Neuroimage. 2012;59:2678-2688.

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