14800-DvRappard

17 General introduction 1 Figure 4 . Axial T2-weighted and sagittal T1 weighted MR images of patients with late-infantile (A), juvenile (B) and adult (C) MLD. (A) shows parietooccipital predominance, involvement of the splenium and the periventricular white matter. In (B) the typical pattern of radiating stripes with bands of normal signal intensity in between is shown. This aspect is highlighted in (D). In the adult patient (C) there is frontal predominance and cerebellar atrophy. In (E) involvement of the splenium is shown in a very early disease stage in a presymptomatic juvenile MLD patient.