14800-DvRappard

Cover design: Ridderprint BV | www.ridderprint.nl Layout: Design Your Thesis | www.designyourthesis.com Printing: Ridderprint BV | www.ridderprint.nl Part of the research in this thesis was funded by the Dutch charity organizationMetakids (project 2015-059), the Hersenstichting (grant WS2015-02) and the Stichting M.O. Knip. The funding agencies had no direct involvement with the contents of the study. Financial support for printing this thesis was kindly provided by the Stichting Researchfonds Kindergeneeskunde, VU University Medical Center, Amsterdam, the Netherlands. Copyright © Diane F. van Rappard, 2018 All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications.