14800-DvRappard

CONTENTS Chapter 1 General introduction 9 I. Clinical aspects Chapter 2 Metachromatic leukodystrophy disease spectrum and approaches for treatment 27 Chapter 3 Slowly progressive psychiatric symptoms: think metachromatic leukodystrophy 49 II. Treatment Chapter 4 Intrathecal baclofen: course of treatment in metachromatich leukodystrophy versus spastic cerebral palsy 61 Chapter 5 Efficacy of hematopoietic cell transplantation in metachromatic leukodystrophy: the Dutch experience 75 Chapter 6 Donor macrophages and remyelination in metachromatic leukodystrophy 89 III. Quantitative MRI Chapter 7 Quantitative MR spectroscopic imaging in metachromatic leukodystrophy: value for prognosis and treatment 105 Chapter 8 Diffusion tensor imaging in metachromatic leukodystrophy 123 IV. Extra-neurological involvement Chapter 9 Gallbladder and the risk of polyps and carcinoma in metachromatic leukodystrophy 143 Chapter 10 Discussion, summary and future perspectives 161 Dankwoord 177 List of publications 181 Curriculum Vitae 183