17 Appendices SUPPLEMENTARY RESULTS Baseline characteristics COIMBRA & APRICOT As the study population of two prospective studies was combined, we first compared patient-related and clinical characteristics of the COIMBRA patients with the APRICOT patients. Differences were assessed using chi-square tests for categorical data and t-tests or Mann-Whitney U-test for continuous data, depending on the distribution of the tested variable. In total, 58 patients underwent cognitive testing for either the COIMBRA (n = 32) or the APRICOT (n = 26) study between November 2020 and January 2023 (Supplementary Table 2). The APRICOT patients had a higher KPS than COIMBRA patients (p = .020), but did not differ regarding any of the other clinical characteristics. Most patients were scheduled to receive SRS (52/58), with 5/58 scheduled for WBRT and one patient for WBRT+SRS. Supplementary Table 2. Baseline characteristics in patient group. Clinical characteristic Total (n = 58) Age, years, median (IQR) 66.0 (57.8 – 72.3) Sex (male), n (%) 31 (53.4) Educational levela, n (%) 3 3 (5.2) 4 10 (17.2) 5 23 (39.7) 6 14 (24.1) 7 8 (13.8) Ravens matrices39 percentile score, median (IQR) 62.5 (37.5 – 84.4) Handednessb, n (%) Left 7 (12.1) Right 48 (82.8) Ambidextrous 3 (5.2) KPS, median (IQR)c 80 (80-90) No. of BMs, n (%) 1 16 (27.6) 2-4 25 (43.1) 5-10 10 (17.2) >10 7 (12.1) Hemisphere involvement BMs, n (%) Left 14 (24.1) Right 12 (20.7)
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