3 Appendices CHAPTER 2 SEARCH STRATEGY Search carried out on January 4th 2021 PICO process: Patient/population: Adult patients with brain metastases Intervention: Whole-brain radiotherapy (WBRT) and/or stereotactic radiosurgery (SRS) Comparison/control: Not applicable Outcome: Objective cognitive functioning Pubmed (“Brain Neoplasms/secondary”[Mesh] OR brain metastas*[Title/Abstract] OR metastatic brain*[Title/Abstract]) AND (Radiotherapy [MESH:NoExp] OR radiotherapy [Subheading] OR Radiosurgery [MESH] OR radiotherap*[Title/Abstract] OR radiation therap*[Title/Abstract] OR brain irradiation [Title/Abstract] OR radiosurg*[Title/Abstract] OR stereotactic radio* [Title/Abstract] OR SRS [Title/Abstract] OR SRT [Title/Abstract] OR gamma Knife [Title/Abstract] OR GKRS [Title/Abstract] OR GKS[Title/Abstract] OR GK[Title/ Abstract] OR whole brain radio* [Title/Abstract] OR WBRT [Title/Abstract]) AND (Neurocognitive Disorders [Mesh:NoExp] OR Cognition Disorders [Mesh:NoExp] OR Cognitive Dysfunction[Mesh] OR cognition [mesh] OR neuropsychology [MESH] OR Neuropsychological Tests [mesh] OR Memory [Mesh] OR Verbal learning [Mesh] OR Learning [Mesh] OR Psychomotor Performance [Mesh] OR Problem Solving [Mesh] OR Executive Function [Mesh] OR Mild Cognitive Impairment [Title/Abstract] OR Cogniti*[Title/Abstract] OR Neuropsychology* [Title/Abstract] OR Neurocogniti* [Title/Abstract] OR NCF [Title/Abstract] OR Memory [Title/Abstract] OR Verbal Learning [Title/Abstract] OR Learning [Title/Abstract] OR Psychomotor Performance [Title/Abstract] OR Problem Solving [Title/Abstract] OR Executive Function [Title/ Abstract] OR Digit Span [Title/Abstract] OR Digit Symbol [Title/Abstract] OR WAIS [Title/Abstract] OR Wechsler* [Title/Abstract] OR WMS [Title/Abstract] OR Trail Making Test [Title/Abstract] OR TMT [Title/Abstract] OR Hopkins Verbal Learning Test [Title/Abstract] OR HVLT [Title/Abstract] OR Hopkins Verbal Learning Test Revised [Title/Abstract] OR Rey Auditory Verbal Learning Test [Title/Abstract] OR RAVLT [Title/Abstract]OR Pegboard [Title/Abstract] OR Controlled Oral Word Association*
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