21 Appendices more likely to have psychomotor speed impairment (67%) than patients without sensory problems (32%, p = .028). There was no differences between the groups with or without motor problems regarding the proportion of psychomotor speed impairments As half of the patients reporting sensory problems, reported those sensory problems to be due to neuropathy. Accordingly, patients were divided into three groups: 1) patients without sensory problems, 2) patients with sensory problems unrelated to neuropathy, and 3) patients with sensory problems due to neuropathy. There was no difference in the number of patients with impaired psychomotor speed performance between patients without sensory problems, neuropathy-unrelated sensory problems and neuropathy-related sensory problems (p = .084). There was no relationship between stress and cognitive deficits within any of the domains (all correlations p > .05). Feasibility of comprehensive test battery The completion rate of the comprehensive NCA battery (all 22 (sub)tests) versus the core test battery (11 subtests) was 52% and 91%, respectively. On average 91% of the 23 subtests of the comprehensive NCA battery were completed, while 52% of the patients completed all 22 (sub)tests (Supplementary Figure 2). Of the core battery, 96% of the tests was completed on average, while 91% of the patients completed the entire battery. The Facial Expressions of Emotion: Stimuli and Tests (FEEST) and Visual Association Test (VAT) were most often not completed, mostly due to time constraints as the brain radiotherapy was planned directly after the NCA (46% and 67% of missing cases, respectively). Of those patients finishing the full NCA (n = 29), median duration was 87 minutes (range 65-126 minutes) with 72% of all patients staying within intended the 90 minutes duration. Cognitive fatigue half-way and at the end of the full NCA was assessed using the Digit Span Forward. At the half-way mark 12/56 (21%) patients and at the end of the NCA 10/44 (23%) showed signs of fatigue (Supplementary Table 5). 6/44 patients (14%) showed signs of cognitive fatigue at both tested time points. Two patients were not able to complete the Digit Span Forward at the half-way mark due to self-reported fatigue. Additionally, nine patients could not finish the Digit Span Forward at the end of the NCA due to time constraints with other clinical appointments and two due to self-reported fatigue. To assess the impact of cognitive fatigue on the cognitive performance, MannWhitney U-tests were performed to compare the mean z-scores per domain
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