23 Appendices Supplementary Table 5. Number and percentage of patient with a difference in maximum span half-way and at the end of the NCA. Difference in maximum span Half-way the NCA End of the NCA 0 44 (78.6%) 34 (77.3%) -1 11 (19.6%) 8 (18.2%) -2 1 (1.8%) 2 (4.5%) Supplementary Table 6. Comparison of mean (SD) z-scores per cognitive domain between patients with and without fatigue either half-way or at the end of the NCA. Fatigue half-way through NCA Fatigue at the end of NCA Yes (n =12) No (n = 44) p-value Yes (n =10) No (n = 34) p-value Attention -0.04 (0.85) 0.13 (0.68) .775 0.02 (0.76) -0.02 (0.69) .634 Executive function -0.10 (0.69) -0.11 (0.94) .795 0.13 (0.92) -0.26 (0.90) .157 Memory -0.78 (1.34) -0.48 (0.80) .889 -0.80 (1.44) -0.46 (0.84) .889 Processing speed -1.35 (1.43) -0.41 (0.98) .006 -0.38 (0.88) -0.28 (0.77) .634 Psychomotor speed -0.83 (1.05) -1.60 (2.86) .542 -0.24 (0.69) -1.52 (3.06) .053 Visuospatial functioning 0.70 (0.60) 0.58 (0.71) .563 0.80 (0.60) 0.59 (0.73) .334 Social cognition -1.22 (1.29) -0.86 (1.05) .611 -0.98 (1.14) -0.89 (1.02) .831 Bold values indicate statistically significant difference between patients with and without fatigue, corrected p-value < .007.
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