24 Supplementary materials Supplementary Table 7. Comparison of the number (%) of patients with cognitive impairment between patients with and without fatigue either half-way or at the end of the NCA. Fatigue half-way through NCA Fatigue at the end of NCA Yes (n =12) No (n = 44) p-value Yes (n =10) No (n = 34) p-value Attention 2 (16.7) 7 (15.9) .949 2 (20.0) 7 (20.6) .968 Executive function 3 (25.0) 9 (20.5) .734 2 (20.0) 9 (26.5) .678 Memory 7 (58.3) 22 (50.0) .609 5 (50.0) 18 (52.9) .870 Processing speed 7 (58.3) 11 (25.0) .028 3 (30.0) 7 (20.6) .532 Psychomotor speed 3 (27.3) 18 (40.9) .405 1 (10.0) 12 (35.3) .123 Visuospatial functioning 0 (0.0) 5 (11.4) .221 0 (0.0) 3 (8.8) .331 Social cognition 3 (50.0) 7 (35.0) .508 2 (28.6) 6 (37.5) .679 Corrected p-value < .007. Comparison between comprehensive versus core battery A severe impairment (-2.0SD) in at least one task within one domain was found for 71% for the comprehensive battery and 59% for the core battery. A more subtle deficit (-1.5SD) for at least one domain was found for 79% on the comprehensive and 71% on the core battery. When using the ICCTF criterion for impairment (≤-1.5SD on ≥2 test or ≤-2.0SD on ≥1 test) 76% of all patients were classified as cognitively impaired when all 10 NCA tests were considered and 60% when only the core battery was taken into account. We additionally examined the effects of using the ICCTF cognitive domain categorization18 on differences between the comprehensive and the core battery. Based on the ICCTF, both the TMT switching ratio (B/A) and STROOP switching ratio (IV vs III) were grouped under the domain of executive function instead of attention. Upon examination, results indicated that all patients with deficits on either the TMT switching ratio (B/A) and STROOP switching ratio (IV vs III) did not show deficits in any of the other executive function tests. Therefore, according to the ICCTF cognitive domain grouping, these patients were categorized as having executive function impairments rather than attention deficits. This indicates the number of cognitive domains found to be impaired with either the comprehensive or the core battery remained the same, regardless of the domain classification that was used. Thus, A
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