29 Appendices Supplementary Table 3. Factors associated with 3 months post-radiotherapy changes in subjective cognitive performance. (continued) Variable Decline, n (%) Improvement, n (%) Mixed, n (%) Stable, n (%) p No 5 (33) 6 (40) 1 (7) 3 (20) .702 Yes 9 (43) 5 (24) 3 (14) 4 (19) No of BMs 1-4 3 (27) 4 (36) 2 (18) 2 (18) .694 ≥5 11 (44) 7 (28) 2 (8) 5 (20) Symptomatic BMs No 6 (29) 8 (38) 4 (19) 3 (14) .118 Yes 8 (53) 3 (20) 0 (0) 4 (27) Synchronous BMs diagnosis No 9 (38) 6 (25) 3 (13) 6 (25) .566 Yes 5 (42) 5 (42) 1 (8) 1 (8) Intracranial progression No 5 (22) 8 (35) 4 (17) 6 (26) .031 Yes 9 (69) 3 (23) 0 (0) 1 (8) Baseline cognitive impairment 0 domains 2 (29) 5 (57) 1 (14) 0 (0) .383 1 domain 3 (27) 3 (27) 4 (36) 4 (36) ≥2 domains 9 (50) 4 (22) 2 (11) 3 (17) Bold values indicate statistically significant differences. Objective neurocognitive functioning Supplementary Table 4. Cumulative percentage of patients with a Z-score below the threshold for all time points and each task and cognitive domain. Cognitive test or domain Baseline 3 months ≥11 months -1 -1.5 -2 -1 -1.5 -2 -1 -1.5 -2 Attention 44.4 19.4 19.4 52.8 30.6 27.8 35.7 14.3 14.3 DS – Forward 27.8 5.6 5.6 19.4 2.8 2.8 0.0 0.0 0.0 TMT - Switching 8.3 2.8 2.8 13.9 11.1 8.3 7.7 0.0 0.0 STROOP - Switching 20.6 14.7 14.7 25.0 19.4 19.4 30.8 15.4 15.4 Executive function 50.0 25.0 16.7 47.2 25.0 13.9 50.0 35.7 28.6 DS – Backward 33.3 13.9 11.1 36.1 8.3 8.3 21.4 7.1 7.1 Letter fluency 27.8 13.9 5.6 27.8 13.9 5.6 21.4 14.3 7.1
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