30 Supplementary materials Supplementary Table 4. Cumulative percentage of patients with a Z-score below the threshold for all time points and each task and cognitive domain. (continued) Cognitive test or domain Baseline 3 months ≥11 months -1 -1.5 -2 -1 -1.5 -2 -1 -1.5 -2 STROOP Inhibition 14.7 5.9 2.9 8.3 5.6 0.0 15.4 15.4 15.4 Learning & memory 72.2 47.2 36.1 94.4 77.8 52.8 78.6 71.4 42.9 HVLT-R - Immediate recall 38.9 30.6 22.2 55.6 41.7 27.8 64.3 42.9 21.4 HVLT-R - Delayed recall 44.4 22.2 16.7 47.2 30.6 22.2 50.0 35.7 21.4 HVLT-R - Delayed recognition 58.3 33.3 33.3 50.0 30.6 30.6 28.6 21.4 21.4 ROCFT - Delayed Recall 13.9 8.3 2.8 11.1 2.8 2.8 23.1 15.4 7.7 VAT - Immediate Recall 21.9 6.3 3.1 41.7 30.6 25.0 50.0 35.7 28.6 VAT - Delayed Recall 3.3 3.3 3.3 5.7 5.7 5.7 30.8 23.1 23.1 Semantic fluency (2min) 22.2 2.8 0.0 47.2 25.0 2.8 21.4 0.0 0.0 Processing speed 41.7 30.6 22.2 36.1 25.0 22.2 69.2 30.8 23.1 TMT - Part A 19.4 11.1 5.6 16.7 11.1 8.3 23.1 15.4 7.7 STROOP - Naming 25.0 16.7 13.9 30.6 22.2 22.2 46.2 7.7 7.7 STROOP - Reading 22.2 16.7 11.1 22.2 16.7 11.1 38.5 23.1 23.1 Psychomotor speed 44.4 36.1 27.8 41.7 38.9 30.6 53.8 38.5 15.4 GP - Dominant hand 41.7 33.3 19.4 30.6 27.8 19.4 46.2 30.8 15.4 GP - Non-dominant hand 33.3 25.0 16.7 33.3 30.6 22.2 33.3 16.7 8.3 Visuospatial functioning 33.3 16.7 16.7 19.4 5.6 5.6 15.4 7.7 7.7 ROCFT - Direct Copy 11.1 8.3 8.3 2.8 2.8 2.8 7.7 7.7 7.7 HVOT – Fragmented 25.0 11.1 11.1 19.4 5.6 5.6 7.7 0.0 0.0 FEEST total 48.0 32.0 16.0 38.7 26.7 16.7 42.9 42.9 14.3 Abbreviations: DS, digit span; FEEST, Facial Expressions of Emotion – Stimuli and Tests; GP, Grooved Pegboard; HVLT-R, Hopkins Verbal Learning Test – Revised; HVOT, Hooper Visual Organization Test; ROCFT, Rey Osterieth Complex Figure Test; TMT, trail making test; VAT, Visual Association Test. A
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