32 Supplementary materials Supplementary Table 5. Factors associated with 3 months post-radiotherapy changes in objective cognitive performance. Variable Decline, n (%) Improvement, n (%) Mixed, n (%) p Age ≤65 3 (15) 0 (0) 17 (85) .488 ≥66 3 (19) 1 (6) 12 (75) KPS ≤80 3 (14) 1 (5) 18 (82) .619 ≥90 3 (21) 0 (0) 11 (79) Primary tumor Lung 3 (18) 0 (0) 14 (82) .629 Other 3 (16) 1 (5) 15 (79) Extracranial metastases No 2 (13) 0 (0) 13 (87) .605 Yes 4 (19) 1 (5) 16 (76) No of BMs 1-4 1 (9) 1 (9) 9 (82) .244 ≥5 5 (20) 0 (0) 20 (80) Symptomatic BMs No 2 (13) 1 (7) 12 (80) .456 Yes 4 (19) 0 (0) 17 (81) Synchronous BMs diagnosis No 5 (21) 0 (0) 19 (79) .251 Yes 1 (8) 1 (8) 10 (83) Intracranial progression No 3 (23) 0 (0) 10 (77) .577 Yes 3 (13) 1 (4) 19 (83) Baseline cognitive impairment 0 domains 2 (29) 1 (14) 4 (57) .099 1 domain 3 (27) 0 (0) 8 (73) ≥2 domains 1 (6) 0 (0) 17 (94) A
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