41 Appendices Supplementary Figure 3. SVR-LSM results for the RAVLT delayed recall for both groups combined when etiology was added as covariate. Panel A shows the lesion overlap for this task when lesions from both groups are combined. The color bar indicates the number of patients with overlapping lesions. Panel B shows the voxels that were significantly associated with worse performance (yellow). The yellow color indicates the p-value for each voxel. Delayed recognition verbal memory (Supplementary Figure 4) Multiple brain areas in of the left hemisphere were significantly associated with task performance in the combined group analysis. Significant grey matter brain areas included the middle temporal gyrus (most voxels with peak significance; 38.1%), the hippocampus (50.0%), the inferior temporal gyrus (32.9%), the parahippocampal gyrus (14.9%), the fusiform gyrus (11.6%) and the superior temporal gyrus (11.2%). Significant voxels extended into white matter areas like the ILF (58.9%), posterior segment (31.4%), optic radiation (31.1%) and the IFOF (14.5%). Although most brain areas overlapped with those found in the etiology specific lesion-symptom maps some brain areas were found in the combined group analysis that were not found when analyzing the groups separately, like the left superior temporal gyrus (Supplementary Figure 4 and Supplementary Table 5). Additionally, all right-sided brain areas that were involved in task performance in the stroke group (inferior and middle frontal gyrus), were not indicated by the combined group analysis.
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