43 Appendices Supplementary Figure 5. SVR-LSM results for the letter fluency for both groups combined when etiology was added as covariate. Panel A shows the lesion overlap for this task when lesions from both groups are combined. The color bar indicates the number of patients with overlapping lesions. Panel B shows the voxels that were significantly associated with worse performance (yellow). The yellow color indicates the p-value for each voxel. Semantic fluency (Supplementary Figure 6) The combined SVR-LSM analyses indicated lesions in the left corticospinal tract (most voxels with peak significance; 14.4%) to be most strongly related to worse semantic fluency performance. Significant voxels extended into grey matter areas, including the caudate nucleus (23.1%) and the precentral gyrus (21.5%). While at large the brain areas found in the etiology specific lesions-symptom maps were also found in the combined lesion-symptom maps, some differences were apparent. For example, the caudate nucleus was only significant when both groups were combined and the left superior dorsolateral frontal gyrus and rolandic operculum were only found in the separate tumor and stroke analyses, respectively. (Supplementary Figure 6 and Supplementary Table 5).
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