65 Appendices NUMERICAL BASELINE PHYSIOLOGICAL VALUES Supplementary Table 2. Group mean values (standard deviation) per MRI metric (OEF, CBF, CMRO2, CVR) per tissue type (WB, GM, WM, edema and Brain metastases). MRI metric GM WM Edema Brain metastases OEF (percentage) 16.9 (1.1) 23.4 (1.5) 15.5 (6.1) 16.0 (4.3) CBF (ml/100ml/min) 41.0 (9.1) 29.6 (7.0) 22.8 (5.2) 46.8 (25.5) CMRO2 (µmol/100g/min) 60.1 (10.7) 53.7 (12.3) 27.9 (13.4) 63.6 (38.1) CVR (∆BOLD/∆PetCO2) 0.17 (0.06) 0.11 (0.04) 0.05 (0.05) 0.10 (0.09) Abbreviations: GM, grey matter; WM, white matter. BREATHING TRACE Supplementary Figure 1. CO2 breathing trace of a representative subject during the breathing challenge. The blue line indicates the actual measured PetCO2 values, while the red line indicates the desired values based on the protocol.
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