Pranav Bhagirath

98 Chapter 5 Geometric remodeling Pre- and post-procedural LASP were significantly lower in patients with paroxysmal AF compared to persistent AF (p=0.02 and p=0.04, respectively) ( table 1 ). The post-procedural change in the left atrial geometry, calculated as the difference between pre-procedural LASP and post-procedural LASP, was significantly related to AF recurrence (p<0.001) ( figure 3 and table 2 ). Patients with AF recurrence following the repeat ablation (n=14) showed an increase of the LASP (negative remodeling) after the index procedure. Eleven patients had a reduction of LASP (positive remodeling) after the index ablation and were free from AF recurrence following the repeat ablation ( table 2 ). The nature of AF was not correlated with changes in the LASP as both negative and positive geometrical changes were observed in paroxysmal as well as persistent AF patient groups ( figure 4 ). Volumetric remodeling Both pre- and post-index procedural LAVi demonstrated no correlation with post- procedural AF recurrence ( table 2 ). Change in the LAVi, calculated as the difference between pre-procedural LAVi and post-procedural LAVi, was also not correlated with AF recurrence (p=0.17). No significant difference was found in the pre-procedural LAVi between paroxysmal AF (61 ± 16 ml/m 2 ) and persistent AF (74 ± 15 ml/m 2 ) (p=0.06). A significant difference was observed in the post-procedural LAVi between paroxysmal AF (57 ± 19 ml/m 2 ) and persistent AF (77 ± 21 ml/m 2 ) (p=0.02). Left atrial remodeling and PV isolation No significant correlation was observed between the volumetric indices and total number of isolated PV’s ( table 3 ). An inverse relationwas found between pre-procedural LASP and total number of isolated PV’s (Pearson’s r=-0.528, p=0.007) ( table 3 ). Post- procedural LASP was not correlated with the total number of isolated PV’s (Pearson’s r=-0.352, p=0.08) ( table 3 ).