Pranav Bhagirath

225 Appendices In Chapter 9 we investigated the possibility of deriving information on the epicardial potentials using only 62 torso electrodes without the aid of a-priori models. Various electrode configuration simulations were used to gain insight and predict probable image quality of different electrode configurations. Application of 62 anterior electrodes with an inter-electrode distance of 20mm enabled reconstruction of an anterior view of the epicardial potentials in the absence of an a-priori model. By increasing the total number of recording electrodes, information on the posterior area of the heart can also be reconstructed using this super-concentrated electrode configuration. In Chapter 10 the IPM workflow was clinically validated in patients undergoing catheter ablation of idiopathic ventricular tachycardia (VT). It was found that using this MRI based IPM method it was possible to estimate the VT focus location with clinically sufficient accuracy using body surface potentials of a single ectopic beat. In addition, a comparison between two independent observers demonstrated an almost perfect reproducibility of the results. The comparison between the homogeneous and inhomogeneous volume conductor models (VCM) indicated a significant difference in favor of the inhomogeneous VCM. In Chapter 11 the main findings of this thesis are summarized and put in clinical perspective.